Clinvet offers various in vitro and in vivo screening models in our laboratories. Several new techniques have been developed and have greatly expanded the application of these principles. In addition to reducing the use of animals in research, these methods reduce the amount of the test compound and provide faster results at a lower cost.
In vitro assays include contact and repellency bioassays and artificial feeding models and systems.
Contact assays (like LPT, LIT, and AIT) and repellency tests use direct exposure of the parasites to an active ingredient, either in solution or on filter paper, glass or other materials.
In artificial feeding assays, systemic compounds can be tested by allowing blood-feeding ectoparasites (like sandflies, mosquitoes and ticks) to feed on treated blood or another media across a synthetic membrane or by allowing endoparasites to move through a medium and assessing their behavior.
Small animal models against ecto- and endo-parasites are also feasible.
We also propose several in vitro motility and larval development assays, dual infection and small animal models for endoparasites.